Boone County is located in the U.S. state of Missouri. Centrally located the state's Mid-Missouri region, its county seat is in Columbia, which is Missouri's fourth-largest city and location of the University of Missouri. As of the 2020 U.S. Census, the county's population was listed as 183,610, making it the state's eighth-most populous county. The county was or…Boone County is located in the U.S. state of Missouri. Centrally located the state's Mid-Missouri region, its county seat is in Columbia, which is Missouri's fourth-largest city and location of the University of Missouri. As of the 2020 U.S. Census, the county's population was listed as 183,610, making it the state's eighth-most populous county. The county was organized November 16, 1820, removed from the former larger Howard County of the old federal Missouri Territory of 1812-1821, and named for the famous Western explorer and settler of Kentucky, then recently deceased Daniel Boone, whose kin largely populated the Boonslick area, having arrived in the 1810s on the Boone's Lick Road.
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