Proteins are essential components of cellular life, uniquely translating genetic information into a vast array of molecular ...

Tau behaves abnormally in the brain in people with Alzheimer’s disease. This latest study points to a reason why.

This important study identifies the "H-state" as a potential conformational marker distinguishing amyloidogenic from non-amyloidogenic light chains, addressing a critical problem in protein misfolding ...

A new study indicates that the loss of brain volume associated with the Alzheimer's drug lecanemab shows the drug is working ...

This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

To determine the diagnostic accuracy of the results of CSF tests compared to the gold standard PET imaging, the Munich researchers evaluated the data of over 400 patients with suspected Alzheimer's ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

Italian researchers have developed a nasal spray showing promise in slowing Alzheimer's progression. Tests on mice with ...

More than 20 unrelated proteins can form amyloid fibrils in ... such as hemorrhage in local respiratory or urogenital tract AL amyloid. Local amyloid deposits are also hallmark pathological ...

the proteins were involved in β2-m amyloid fibril formation. More information: Suguru Yamamoto et al, Mass spectrometry-based ...