Reactive oxygen species are enhanced in ALI and propagate inflammatory cascades and lung injury. Antioxidants can attenuate ALI in animal models, and clinical trials evaluating the benefit of ...

Consistent with the principles of the 3Rs in Animal Experimentation (Hubrecht and Carter, Animals (Basel) 2019, 9, 754) ...

Our research encompasses the development of animal models such as the smoke mouse model of COPD, lung bacterial infection mouse model ... that these molecules impact during self-limited tissue injury ...

They also show that VECs differentiate into capillary cells, and that this remodeling is a response to lung injury ... explains that past studies on these animals suggested that "at least in ...