Breast cancer remains a leading health crisis worldwide, claiming the lives of approximately 685,000 women in 2020 alone.

Endocrine therapy against the estrogen receptor (ER) is widely used for the treatment of ER+ breast cancer. Selective estrogen receptor degraders (SERDs) compete directly with estrogen for ER binding ...

G-protein coupled receptors regulate hormone secretions in the pancreas. Learn how the complex signaling features of these receptors are illuminating diabetes research. Diabetes results from ...

a PROTAC protein degrader targeting the estrogen receptor protein for the treatment of patients with metastatic ER positive/HER2 negative breast cancer. The company was founded in February 2013 ...

Estrogen and progesterone ... with the androgenic receptor. On the other hand, progestins counter the beneficial estrogen effect on SHBG by reducing this binding protein in serum, thus being ...