Background: The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to ...

Hydroxyurea is used to study how and when a cell halts the replication process by activating these stopping points for study ...

Our investigation provides powerful justifications for hydroxyurea's use in children with sickle cell anemia in Africa. Given the high rates of infection in this region, we hope our evidence will ...

Avoid vaccination while taking this medication. Treatment of children with sickle-cell anemia in Africa, with an escalated dose of hydroxyurea, resulted in better clinical outcomes. The adverse ...

The quality of life of patients with sickle cell anemia is severely compromised ... Patients who responded to hydroxyurea therapy had improvement in certain aspects of quality of life including ...