They were able to identify a previously unknown signaling pathway in human cells that is driven by the protein SPG20. It recognizes damage to the outer side of the lysosomal membrane, binds to the ...

Stress granules (SGs) form in response to diverse environmental signals. Here, the signaling pathways that connect lysosomal ...

"Cytosolic DNA is a danger signal associated with infections ... indicating that STING-induced autophagy-lysosome pathway is ...

LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor ...

This project is to determine TFEB PTM signatures induced by tau that drive TFEB nuclear signaling. The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate ...

TFEB regulates lysosomal exocytosis of tau and its loss of function ... tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways. M.Proc Natl Acad Sci U ...

Cell signaling is also pivotal for multi-cellular ... by cells to degrade various cellular components via the lysosomal pathway, and fulfills numerous functions in processes such as development ...

“The endo-lysosomal, immune, and lipid trafficking pathways are highly interrelated as lipids and ... So far, the findings suggested that subpar lysosomal function, or overactive interferon signaling, ...

Crucially, Salmena and his team also identified the signaling pathway by which INPP4B drives the movement of lysosomes to the cell edge. INPP4B works with two other proteins—PIKfyve and TRPML-1 ...

For instance, proteins that are destined for the vacuoles/lysosomes are synthesized ... or participate in a signaling pathway. Although endosomal systems are heavily characterized in animal ...

AMPK signaling promotes an increase in cell stiffness ... sense amino acids but also to act as an important regulator of lysosome physiology. We have now also identified a second, parallel pathway ...