Recent studies suggest that these granules can "hitch a ride" from lysosome-related vesicles, membrane-bound structures in cells that share common characteristics with lysosomes. Researchers at ...

were the first to suggest that these particular vesicles were pre-lysosomes (Smith & Farquhar 1966). Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore.

Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...

They identified two distinct modes of endosomal fusion: homotypic fusion, where two endosomes fuse rapidly to form a single ...

At the time, the authors proposed that these vesicles fused with the plasma membrane, releasing their acidic contents and fueling amyloidosis. Nixon favors the idea that microglial cell death, caused ...

7). LC3 lipidation occurs on endocytic vesicles immediately prior to lysosome fusion and is required for the efficient degradation of engulfed substrates, suggesting that these scavenging pathways ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...