The effective targeting of RAS-mutant acute myeloid leukemia (AML) still remains a challenge; RAS mutations are tied to relapse to targeted therapy, such as resistance to FLT3 inhibitors due to the ...

Study: Different RAS mutations each have unique impact on AML, drug response Approximately 10% to 20% of patients with acute myeloid leukemia (AML) have a mutation in the RAS genetic pathway at ...

RAS-family mutations are associated with numerous ... NRAS mutations are often observed in melanoma, acute myeloid leukemia, ...

With the Oncology Brothers, Uma Borate, MD, discusses how CPX-351 demonstrates superior efficacy over 7+3 chemotherapy in ...

Dr. Ruemu Birhiray explains chronic myeloid leukemia (CML), its treatment options, and what patients should know about this ...

Oct. 9, 2024 — Researchers have created a CRISPR-based rapid molecular diagnostic for two forms of leukemia that are driven by mutations ... a mechanism by which acute myeloid leukemia (AML ...

Jan. 17, 2020 — A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), one of the most common forms of blood cancer. The ...

acute myeloid leukemia (AML). "Some people call it AML -- I like to make the distinction and call it accelerated or a blast-phase MPN, because it does behave a little bit differently than just ...

ALL = Acute lymphoblastic leukemia; AML = Acute myeloid leukemia; FTI = Farnesyltransferase inhibitor; HDAC = Histone deacetylase; NF = Nuclear factor; Ph = Philadelphia chromosome; TKI = Tyrosine ...

Researchers at University of California San Diego School of Medicine and their colleagues have developed the first comprehensive map of the dramatic changes that take place in the blood system over ...