Proteins are essential components of cellular life, uniquely translating genetic information into a vast array of molecular ...

A new study from the University of Liverpool significantly advances the understanding of Alzheimer’s disease. Researchers ...

This important study identifies the "H-state" as a potential conformational marker distinguishing amyloidogenic from non-amyloidogenic light chains, addressing a critical problem in protein misfolding ...

A University of Liverpool study links Alzheimer’s disease to disrupted mechanical signaling between proteins APP and talin in ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

Amyloid light-chain (AL) amyloidosis is a bone marrow disorder that, like ATTR-CM, is caused by misfolded proteins. Although ...

More than 20 unrelated proteins can form amyloid fibrils in ... such as hemorrhage in local respiratory or urogenital tract AL amyloid. Local amyloid deposits are also hallmark pathological ...

the proteins were involved in β2-m amyloid fibril formation. More information: Suguru Yamamoto et al, Mass spectrometry-based ...

AL amyloidosis (also called primary amyloidosis ... Daratumumab targets a protein found on plasma cells and can have a direct effect on killing abnormal cells while also marking these cells ...

How exactly do amyloid plaques affect surrounding brain tissue ... “This is an important contribution that directly links the age of aggregated protein with overall disease pathology—reinforcing that ...