In mice, inhibiting protein S-palmitoylation Counteracted accumulation of harmful proteins in neurons and delayed onset and progression of cognitive decline.

A new study indicates that the loss of brain volume associated with the Alzheimer's drug lecanemab shows the drug is working ...

This important study identifies the "H-state" as a potential conformational marker distinguishing amyloidogenic from non-amyloidogenic light chains, addressing a critical problem in protein misfolding ...

A loss of brain volume associated with new immunotherapies for Alzheimer's disease may be caused by the removal of amyloid ...

Proteins are essential components of cellular life, uniquely translating genetic information into a vast array of molecular ...

Italian researchers have developed a nasal spray showing promise in slowing Alzheimer's progression. Tests on mice with ...

Behold the Body. Electron microgram of a Biondi body shows a dense core surrounded by filaments that bind gold-labeled secondary antibody to TMEM239 (black dots). [Courtesy of Ghetti et al., 2024.] ...

An international collaboration led by RIKEN researchers has discovered how unusual spherical structures form in the brains of ...

The earlier MCI due to AD and mild AD dementia are diagnosed and treated, the greater the opportunity for benefit.

More than 20 unrelated proteins can form amyloid fibrils in ... such as hemorrhage in local respiratory or urogenital tract AL amyloid. Local amyloid deposits are also hallmark pathological ...

A nasal spray drug can counteract the cognitive decline and brain damage typical of Alzheimer's disease in animal models.