Proteins are essential components of cellular life, uniquely translating genetic information into a vast array of molecular ...

A new study from the University of Liverpool significantly advances the understanding of Alzheimer’s disease. Researchers ...

A University of Liverpool study links Alzheimer’s disease to disrupted mechanical signaling between proteins APP and talin in ...

This important study identifies the "H-state" as a potential conformational marker distinguishing amyloidogenic from non-amyloidogenic light chains, addressing a critical problem in protein misfolding ...

This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

A new study indicates that the loss of brain volume associated with the Alzheimer's drug lecanemab shows the drug is working ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

Italian researchers have developed a nasal spray showing promise in slowing Alzheimer's progression. Tests on mice with ...

More than 20 unrelated proteins can form amyloid fibrils in ... such as hemorrhage in local respiratory or urogenital tract AL amyloid. Local amyloid deposits are also hallmark pathological ...

the proteins were involved in β2-m amyloid fibril formation. More information: Suguru Yamamoto et al, Mass spectrometry-based ...