The Detroit Lions are visiting the Indianapolis Colts in a game that could be decided by three on-field matchups.

Alternate uniforms lead the way in Week 12 of the NFL season.

Manning, more than anyone, knows the attention and conflicting emotions of these games. He had to go through it three times ...

As the Colts cling to their playoff hopes, who else should you be rooting for this week to help Indianapolis out?

While Week 12 didn't spark major movement in the NFL playoff picture, several contenders had setbacks that could come back to ...

The Detroit Lions are 3-0 against AFC South teams this season, beating the Titans, Jaguars and Texans by a combined score of ...

The Indianapolis Colts and Detroit Lions announced 12 inactive players ahead of Sunday afternoon's Week 12 matchup.

Ryan Curtis menaces attackmen like his father did quarterbacks. Mike Curtis was at the core of the only Baltimore football team to win a Super Bowl, a middle linebacker so nasty he would actually ...

J-Mac is backing the Colts to cover against the Lions, and he's putting his money on the Chargers in Monday Night Football's ...

SUNDAY What looked like a snoozer of an early window turned into a wild three hours. We saw wild finishes in Chicago and ...

Ladd McConkey and Josh Downs are among UPI senior sports writer Alex Butler's four must-start wide receivers for Week 12 of ...

According to NFL.com, Indianapolis’ playoff odds sit at 28 percent heading into this week’s game. With a win, their odds jump ...