Within the granules the enzyme displayed only fractional activity due to its inaccessibility to substrate ... type of subcellular particle, the lysosome 2.

The protein component of HAMLET is α-lactalbumin, which in its native state acts as a substrate specifier in ... proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly ...

MIPLYFFA, the first FDA-approved treatment for Niemann-Pick disease type C, is available at Zevra’s specialty pharmacy for ...

MIPLYFFA has also been shown to reduce unesterified cholesterol in the lysosomes of human NPC fibroblasts ... transporter and may increase the exposure of drugs that are OCT2 substrates. When MIPLYFFA ...

This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...

Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...

Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the ...

This handbook contains a comprehensive collection of protocols to streamline imaging workflows and ensure reproducible ...

This important study identifies a short amino acid sequence that, when fused in multimeric form to the amino termini of luminal ER proteins, initiates proteasomal degradation via the Hrd1 ER quality ...

Gravel, sand, specialist planting substrates - there's a lot of choice out there when it comes to what to put at the bottom of your tank. Matt Clarke answers some frequently asked questions about ...

Substrates or subfloors are the surfaces on which floorcovering materials are applied. They can be wood, concrete, plywood, stone or metal. Regardless of the material, there are specific ...