eLife2d
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells
Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...
The Lancet3d
Targeting sphingosine-1-phosphate receptor modulator in SLE: a promising new therapeutic option
The 2021 approval by regulatory agencies of belimumab, a B lymphocyte stimulator (BLyS) inhibitor, and the 2022 approval of anifrolumab, a type I interferon inhibitor, has increased the therapeutic ...
Paper authored by institute scientists sheds light that better understands colorectal cancer
A team of researchers led by Professor Ningling Kang, PhD, at The Hormel Institute, University of Minnesota, has published an ...
FiercePharma11d
Cleanup for the IL-23 class in ulcerative colitis as new drugs 'rapidly gained significant momentum': report
AbbVie’s off-patent TNF blocker is, however, now being succeeded by cheaper biosimilars, namely Boehringer Ingelheim’s ...
pharmaphorum4d
Data sets up ulcerative colitis expansion for BMS’ MS drug Zeposia
Oral sphingosine 1-phosphate (S1P) 1 and 5 receptor agonist Zeposia (ozanimod) achieved all its targets in the True North trial involving adults with moderate-to-severe ulcerative colitis ...
Medscape21h
Fingolimod for the Treatment of Relapsing Multiple Sclerosis
Sphingosine is a membrane component in all cells and constitutes 25% of the lipid in the myelin sheath. Sphingosine is phosphorylated by ubiquitously expressed sphingosine kinases. S1P regulates ...
ahajournals.org18d
Abstract 4142656: The Lack of Sphingosine Kinase 1 in Smooth Muscle Cells Protects Mice Against Angiotensin II-Induced Hypertension
Introduction: The function of the cardiovascular system is regulated by sphingosine-1-phosphate (S1P) signaling. Vascular sphingosine kinase 1 (Sphk1), an S1P-producing enzyme, is upregulated in ...