eLife2d
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells
Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...
The Lancet3d
Targeting sphingosine-1-phosphate receptor modulator in SLE: a promising new therapeutic option
The 2021 approval by regulatory agencies of belimumab, a B lymphocyte stimulator (BLyS) inhibitor, and the 2022 approval of anifrolumab, a type I interferon inhibitor, has increased the therapeutic ...
Austin Daily Herald4d
Paper authored by institute scientists sheds light that better understands colorectal cancer
That pathway involves a chain reaction of events from a lipid called sphingosine-1-phosphate (S1P), protein kinase M zeta ...
FiercePharma11d
Cleanup for the IL-23 class in ulcerative colitis as new drugs 'rapidly gained significant momentum': report
AbbVie’s off-patent TNF blocker is, however, now being succeeded by cheaper biosimilars, namely Boehringer Ingelheim’s ...
Medscape18d
FTY720 (Fingolimod) for Relapsing Multiple Sclerosis
FTY720 is a structural analogue of sphingosine that, after conversion to the biologically active FTY720-phosphate molecule, binds with high affinity to sphingosine-1-phosphate receptors to act as ...
ahajournals.org19d
Abstract 4120623: Sphingosine Kinase 1 Is Integral For Elastin Deficiency-induced Arterial Hypermuscularization
Introduction: Defective elastic lamellae and smooth muscle cell (SMC) accumulation are characteristics of diverse obstructive arterial diseases (e.g., atherosclerosis, pulmonary hypertension, and ...
Medscape28d
FTY720 (Fingolimod) for Relapsing Multiple Sclerosis
FTY720 (fingolimod) is a structural analogue of sphingosine, an endogenous lysophospholipid, which targets sphingosine-1-phosphate receptors after biotransformation to FTY720-phosphate.