ASC then polymerizes to form a large aggregate known as ASC speck. In turn, polymerized ASC interacts with the cysteine protease caspase-1 to form a complex termed the inflammasome. This multicomplex ...

Inflammatory caspases are cysteine protease zymogens whose activation following ... Binding of bacterial LPS to its cytosolic sensor, caspase-11 (Casp11), promotes Casp11 aggregation within a ...

Execution of apoptosis involves release of mitochondrial proteins through changes in mitochondrial permeability, and is mediated by caspases, a class of cysteine proteases that cleaves key ...

One of the most common types of brain cancer, glioma, emerges when harmful mutations take place in the ‘glial’ cells tasked with supporting neurons. When these genetically damaged cells are not fixed ...