However, the mechanism through which Sld3 regulates CMG complex formation remains unclear. Here, we present the structure of the Sld3 Cdc45-binding-domain in complex with Cdc45 (Sld3CBD–Cdc45), ...

The University of Vermont Board of Trustees approved the creation of the Vermont Complex Systems Institute (VCSI) at its annual Fall meeting Friday at the Dudley H. Davis Center. The proposed ...

Here, we show that a core regulator of chromosome architecture -the Smc5/6 complex- plays a crucial role in the removal of R-loop structures formed during gene transcription. Consistent with this, ...