It describes recent evidence that SUN1 and SUN2 orchestrate a mechanosensing response that extends both inward to the nuclear chromatin and outward to cell-cell and cell-matrix junctions. The authors ...

We show that TPR is required for the activation of innate immune signalling at these early stages of senescence and we link this to the formation of heterochromatin-enriched cytoplasmic chromatin ...

Repetitive variations, such as oscillation, are ubiquitous in biology. In this mini review, we present a general summary of the ∼24 h circadian clock and provide a fundamental overview of another ...

Spatial organization of chromatin plays a critical role in genome regulation. Previously, various types of affinity mediators and enzymes have been attributed to regulate spatial organization of ...