Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...

Rita Marker, a longtime advocate against assisted suicide, died Oct. 30 at the age of 83. Born in Washington state in 1940, Marker and her family settled in Steubenville, Ohio. After attending an ...

Average expression of the marker gene in each cell cluster is signified by the ... (B) Heatmap illustrates expression of lysosome KEGG pathway genes in LREs and close clusters. The colored bars at the ...

The current work by Rappe et al (2024) has now used the mitoQC reporter mouse to study the density of mitolysosomes, namely mitochondria that have been delivered to lysosomes ... mouse where the ...

Scientists led by Mikael Simons of the German Center for Neurodegenerative Diseases in Munich report that, within the bowels of microglial lysosomes, ApoE forms fibrillar aggregates alongside Aβ.

THE recent enthusiasm for organ transplantation has stimulated increased investigation into the problems of organ storage. In particular, the kidney is being extensively studied because of the ...

These markers, including Rab5, RAB-5 ... and they showed that cells deficient in both factors displayed similar defects in late endosomes/lysosomes. However, the authors didn't confirm whether and/or ...

Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm. A recent collaborative study has discovered rare ...

Panel A shows the results of a wild-type individual (No.1, 219-bp fragment only), a E8SJM heterozygote (No. 2; 219- and 239-bp fragments), and a E8SJM homozygote (No. 3; 239-bp fragment only) together ...