Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...

FDA approval of MIPLYFFATM and product launch cap third quarter filled with multiple commercial and clinical development milestones Zevra ...

Gravel, sand, specialist planting substrates - there's a lot of choice out there when it comes to what to put at the bottom of your tank. Matt Clarke answers some frequently asked questions about ...

Corydoras like to root around in the substrate for food. So what should we use in the aquarium to allow them to behave naturally, without damage to their barbels? Heiko Bleher explains. I strongly ...

Scientists led by Mikael Simons of the German Center for Neurodegenerative Diseases in Munich report that, within the bowels of microglial lysosomes, ApoE forms fibrillar aggregates alongside Aβ.

THE recent enthusiasm for organ transplantation has stimulated increased investigation into the problems of organ storage. In particular, the kidney is being extensively studied because of the ...

Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou 515063, China ...

The polymerization was carried out for 3 h at 40 °C with weak oscillation. After ATRP, 1 M EDTA-4Na aqueous solution was dropped onto the substrate and left for 15 min. Substrates were then rinsed ...

Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood. Evidence links this disorder with ...

Smaller fractions of the N-glycoproteome reside in the ER (5%), Golgi (4%), or lysosomes (2%). UGGT substrates are therefore significantly enriched for lysosomal proteins compared to the ...