Systemic amyloidoses are potentially lethal ... amyloidosis and intensive chemotherapy in immunoglobulin light chain (AL) amyloidosis. These therapies often elicit substantial morbidity and ...

Previously known as primary amyloidosis, systemic amyloid light chain (AL) amyloidosis is the most common form of systemic amyloidosis in developed countries. Although occasionally localized and ...

According to Alnylam’s Tim Mooney, mivelsiran’s endurance is due to stabilizing tweaks the scientists made to the siRNA ...

Systemic amyloidosis is a rare ... 1 Workflow for diagnosis of the type of amyloidosis in case of suspicion. Legend AA - A amyloidosis; AL - light chain amyloidosis; ATTRv - hereditary transthyretin ...

Khan LA, Noor I, Siddique A, et al. Artificial intelligence-enhanced electrocardiogram for the diagnosis of cardiac amyloidosis: a systemic review and meta-analysis. Presented at: AHA Scientific ...

Some such clues are depicted in the Table. Our patient has evidence of conduction disease and has signs of LVH on his echocardiogram without systemic hypertension. Although cardiomyopathy due to AL ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

This important study identifies the "H-state" as a potential conformational marker distinguishing amyloidogenic from non-amyloidogenic light chains, addressing a critical problem in protein misfolding ...

BridgeBio Pharma (BBIO) wins FDA nod Attruby for rare heart disorder, ATTR-CM challenging Pfizer's (PFE) Vyndaqel. Read more ...