Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

Heavy, lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

Head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, DL Nick Bosa and others and discussed the team's ...

The San Francisco 49ers are encouraged by linebacker Dre Greenlaw's progress as he works his way back from a torn Achilles ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...

The San Francisco 49ers are looking broken this season. The post GM John Lynch Loses His Cool on Kyle Shanahan and 49ers as ...

There's no two ways about it: the San Francisco 49ers are having a brutal season. Taking the field in Week 1 with sky-high ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 13 matchup vs. the Buffalo Bills.

San Francisco will be without two of their biggest stars again, but should have their talented passer back in the saddle.