Animal models of acute lung injury - PubMed
We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli.
Animal Models of Acute Lung Injury - American Thoracic Society
The lung injury is characterized physiologically by a fall in lung compliance and lung volumes (eg, functional residual capacity, FRC). The lung injury is characterized histologically by areas of necrosis, acute neutrophilic inflammation, hemorrhage and intra-alveolar and interstitial edema.
Human models of acute lung injury - PMC - National Center for ...
In this article, we consider the clinical features of ALI, discuss the limitations of current animal models and highlight how emerging human models of ALI might help to answer outstanding questions about this syndrome.
A modified “double-hit” induced acute lung injury model in rats …
We focused on the production and evaluation of a modified “double-hit” induced acute lung injury (ALI) model, which closely mimics the clinical situation. Further, tetramethylpyrazine (TMP), an alkaloid contained in ligustrazine was evaluated for its potent anti-inflammatory effects in this model. Rats were randomized into 4 groups: G1 (NS ...
Mouse Models of Acute Lung Injury and ARDS - PubMed
Direct lung infection is the leading cause of ARDS and can be modeled in mice using sterile models of inflammation or live pathogens. In this chapter, two mouse models for ARDS are defined.
Lipopolysaccharide-induced murine lung injury results in long …
Lipopolysaccharide (LPS)-induced injury is a valuable murine model of ALI but there is a paucity of data on lung regeneration and the role of angiogenic signaling involving vascular endothelial growth factor (VEGF).
Comparison of direct and indirect models of early induced acute lung injury
Dec 18, 2020 · To compare different experimental animal models of ALI, based on direct or indirect mechanisms of lung injury, to characterize a model which more closely could reproduce the acute phase of human ARDS.
Characterization of acute lung injury in the bleomycin rat model
Acute lung injury (ALI) is a clinical disease marked by respiratory failure due to the disruption of the epithelial and endothelial barrier, flooding of the alveolar compartment with protein‐rich fluid, and recruitment of neutrophils into alveolar space (Manicone, 2009; Zhao et al., 2021).
The value of the lipopolysaccharide-induced acute lung injury model …
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a syndrome characterized by pulmonary edema and acute inflammation. Lipopolysaccharide (LPS), a major component in Gram-negative bacteria, has been used to induce ALI/ARDS.
A novel animal model of primary blast lung injury and its …
Mar 7, 2022 · In this study, we established an animal model of PBLI using a self-made mini shock tube simulation device. Pathological changes of PBLI mice were characterized by mechanical damage and inflammatory response in lung tissue. KEY WORDS: Lung, blast injury, animal model, shock wave, inflammation.
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