Preclinical murine models to study lung infection with …
Jan 1, 2023 · Overview of preclinical murine models of M. abscessus lung infection. (A) Smooth and rough colony morphotypes of M. Abscessus. (B) Immunocompetent and immunodeficient genotypes of mice considered for M. abscessus infection studies. (C) Routes of M. abscessus infection in mice.
Murine Acute Pneumonia Model of Pseudomonas aeruginosa Lung Infection …
We have been utilizing an acute pneumonia model to study bacterial colonization in lungs and assess virulence to the host by determination of bacterial loads and survival assays, as well as examine the bacterial gene expression in vivo. Additionally, the host's immune response to the pathogen can be explored through this infection model.
Variability of murine bacterial pneumonia models used to …
Sep 8, 2022 · Our review focused on murine lung infection models of the most relevant MDR Gram-negative pathogens, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii, used in proof-of-concept and/or primary pharmacology studies …
Bacterial Lung Infection Models | Charles River
Assess novel lung infection treatments with Charles River's murine models, targeting Pseudomonas aeruginosa, Streptococcus pneumoniae, and more.
Lethal murine infection model for human respiratory disease …
A lethal PRV strain Miyazaki-Bali/2007 murine infection model was established. ... Here we report a lethal lung infection model of PRV strain Miyazaki-Bali/2007 (MB) isolated from a patient with acute respiratory infection (Yamanaka et al., 2014) in adult, immunocompetent inbred mice. We identified significant differences in the susceptibility ...
Preclinical murine models to study lung infection with ... - PubMed
This review discusses the murine models available focusing on the different bacterial challenges (aerosol, intranasal, intratracheal, and intravenous administrations), murine genetic background, and additional bacterial related factors.
Ex vivo infection of murine precision-cut lung tissue slices with
Nov 22, 2020 · In this work, we describe the evaluation of an infection model with a virulent strain of M. abscessus using murine precision-cut lung tissue slices. Once infection was established, we evaluated the antimicrobial activity of tigecycline and imipenem against the infected lung slices.
Murine Acute Pneumonia Model of Pseudomonas aeruginosa Lung Infection
Nov 5, 2020 · We have been utilizing an acute pneumonia model to study bacterial colonization in lungs and assess virulence to the host by determination of bacterial loads and survival assays, as well as examine the bacterial gene expression in vivo. Additionally, the host's immune response to the pathogen can be explored through this infection model.
Expert workshop summary: Advancing toward a standardized murine model …
Sep 8, 2022 · Here we summarize the factors of variability that we identified in murine lung infection models used for antimicrobial efficacy testing, as well as the workshop presentations, panel discussions and the survey results for the harmonization of key experimental parameters.
Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic ...
Our objective was to investigate the anti-inflammatory effect of RTD-1 in a murine model of chronic P. aeruginosa lung infection. Mice received nebulized RTD-1 daily for 6 days. Bacterial burden, leukocyte counts, and cytokine concentrations were evaluated.
- Some results have been removed