Mouse Models of Rheumatoid Arthritis - PubMed
This review aims to integrate morphologic features with model biology and cover the key characteristics of the most commonly used induced and spontaneous mouse models of RA. Induced models emphasized in this review include collagen-induced arthritis and antibody-induced arthritis.
Rheumatoid arthritis animal model in mice - ScienceDirect
Jun 25, 2024 · Animal models of RA are critical in understanding the disease's pathogenesis and the effectiveness of drug treatments. This review summarizes the most recent progress in developing mouse models of autoimmune arthritis to serve as a reference for the study of experimental animal models that are more similar to the pathological features of human RA.
Humanized Mouse Models of Rheumatoid Arthritis for Studies …
Humanized mouse models of rheumatoid arthritis based on the engraftment of human cells and/or tissues in immunodeficient mice. RA-like features (green color) and drawbacks (red color) of the five main approaches for the development of a humanized mouse model of …
The use of animal models in rheumatoid arthritis research
Improved transplantation techniques for severe combined immunodeficiency (SCID) mouse models of RA can be used to evaluate the effectiveness of potential therapeutics in human tissues and cells. This review provides basic information on various animal models of …
Collagen-Induced Arthritis: A model for Murine Autoimmune Arthritis
Collagen-induced arthritis (CIA) is a common autoimmune animal model used to study rheumatoid arthritis (RA). The development of CIA involves infiltration of macrophages and neutrophils into the joint, as well as T and B cell responses to type II collagen.
Frontiers | How to Model Rheumatoid Arthritis in Animals: From …
May 25, 2022 · A study has shown that a citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of RA . The ACPA-induced arthritis murine model is significant for the in-depth study of citrullinated protein antibody-positive RA pathogenesis and the development of new drugs (17–19).
Collagen-induced arthritis - Nature Protocols
May 17, 2007 · While each of these models has advantages and disadvantages, CIA has been the most widely studied model of rheumatoid arthritis (RA). It shares several pathological features with RA, and CII is...
Mouse Models of Rheumatoid Arthritis - SAGE Journals
Jun 10, 2015 · Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder characterized by synovitis that leads to cartilage and bone erosion by invading fibrovascular tissue. Mouse models of RA recapitulate many features of the human disease.
Mouse Models of Rheumatoid Arthritis for Studies on …
Jun 22, 2020 · Mouse models of RA have been extensively used to model the pathogenesis of RA and to develop effective therapies. Although many components of the immune system have been studied in these models, the role of crystallizable fragment (Fc) gamma receptors (FcγRs) in RA has been sorely neglected.
Mouse Models of Rheumatoid Arthritis for Studies on ... - PubMed
Mouse models of RA have been extensively used to model the pathogenesis of RA and to develop effective therapies. Although many components of the immune system have been studied in these models, the role of crystallizable fragment (Fc) gamma receptors (FcγRs) in RA has been sorely neglected.