Real-Time Imaging of HIF-1α Stabilization and Degradation
Apr 4, 2009 · We developed two HIF-1α chimeric reporter systems, HIF-1α/FLuc and HIF-1α (ΔODDD)/FLuc, to investigate the tightly controlled level of HIF-1α protein in normal (NIH3T3 and HEK293) and glioma (U87) cells.
Role of the HIF‑1α/SDF‑1/CXCR4 signaling axis in ... - PubMed
The present study aimed to determine the role of HIF‑1α/SDF‑1/CXCR4 signaling in the process of accelerated fracture healing during craniocerebral injury. Cultured MSCs underwent HIF‑1α knockdown to elucidate its effect on the proliferative ability of MSCs, and the effect of SDF‑1 in MSCs was investigated.
Transcriptional Regulation by Hypoxia Inducible Factors - PMC
We discuss here how the various HIF polypeptides, their post-translational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
Structural integration in hypoxia-inducible factors - Nature
Aug 5, 2015 · This study describes the long-awaited crystal structures for hypoxia-inducible factor (HIF) heterodimers, including complexes bound to small molecules and DNA; the HIF–ARNT architecture is ...
Hypoxia signaling in human diseases and therapeutic targets
Jun 20, 2019 · Hypoxia activates the hypoxia signaling pathway, which is predominantly governed by hypoxia-inducible factor (HIF) stabilization (Fig. 1). In normoxic conditions, the proline residues of HIF-α...
Hypoxia and HIF Signaling: One Axis with Divergent Effects - MDPI
Jun 26, 2020 · Among them, hypoxia-inducible factor (HIF) represents the master regulator of the hypoxia response. The active heterodimeric complex HIF α/β, binding to hypoxia-responsive elements (HREs), determines the induction of at least …
Structural integration in hypoxia-inducible factors - PubMed
Aug 20, 2015 · The DNA-reading head rotates, extends and cooperates with a distal PAS domain to bind hypoxia response elements. HIF-α mutations linked to human cancers map to sensitive sites that establish DNA binding and the stability of PAS domains and pockets.
Macrophage migration inhibitory factor promotes heterotopic ...
MIF, which mediates the ROS/HIF-1α/MIF positive feedback loop during the hypoxic phase of HO, triggers the Wnt/β-catenin signaling pathway to enhance the osteogenic differentiation and formation of HO in TDSCs.
Fractal Analysis of BOLD Time Series in a Network Associated With ...
FMRI studies using H on regional fMRI time courses used fractality as an important characteristic to unravel neural networks from artificial noise. In this fMRI-study, we examined 103 healthy male students at rest and while performing the 5-choice serial reaction time task.
In Silico Exploration of AHR-HIF Pathway Interplay: Implications …
Sep 5, 2024 · In this study, we used protein–protein interaction networks and gene expression profiling to characterize the impact of VHL loss on AHR activity. Our findings reveal specific expression patterns of AHR interactors following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in ccRCC.