Butylated hydroxytoluene (BHT) induction of pulmonary
Butylated hydroxytoluene (BHT) administration to mice causes lung injury and a subsequent inflammatory response, and when administered chronically to certain inbred strains following carcinogen treatment, increases lung tumor multiplicity.
Temporal evolution of epithelial, vascular and interstitial lung injury ...
Nov 22, 2007 · BHT, which is the antioxidant butylated hydroxytoluene, accumulates predominantly in the lung and induces alveolar epithelial damage because of its action on type I pneumocytes (TIp) (Hirai et al. 1977), which is followed by the proliferation of pulmonary parenchymal cells.
Butylated hydroxytoluene induces type-V collagen and ... - PubMed
Butylated hydroxytoluene (BHT) injury model revealed a distal involvement of lung parenchyma with significant endothelial injury and fibrotic response, contrasting with the BLM airway-centered insult.
Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT ...
Jan 1, 1989 · Amounts of retained BHT are negligible; 4hr after BHT, only 0.14% of the administered dose can be found in the lung and after 2 and 4 days, only 0.04% and 0.03% of administered BHT is still in the lung.
Nrf2 is essential for protection against acute pulmonary injury ... - PNAS
Oct 26, 1999 · BHT treatment by either means causes transient lung damage because of the destruction of alveolar type I epithelial cells. Lungs from BHT-treated mice show damage to the alveoli with massive edema and hemorrhage.
β-Catenin in the Fibroproliferative Response to Acute Lung Injury
Nov 4, 2005 · The noncanonical cadherin–β-catenin axis is associated with fibroproliferative repair after BHT/hyperoxia exposure and may regulate epithelial proliferation and lung matrix remodeling and repair in response to lung injury.
Changes in Pulmonary ATP-Binding Proteins Induced by Treating …
Studies show that BHT induces reversible acute pulmonary toxicity that includes alveolar type I cell necrosis followed by a repair process involving proliferation of type II, endothelial, and interstitial cells.
Lung injury induced by butylated hydroxytoluene: cytodynamic …
It is concluded that the proliferative pulmonary changes that occur after the administration of butylated hydroxytoluene are a consequence of cell injury and necrosis. The reparative processes occur predominantly at the alveolar epithelium and interstitium with the production of fibrosis.
toluene (BHT) injury model revealed a distal involvement of lung parenchyma with significant endothelial injury and fibrotic response, contrasting with the BLM airway-centered insult. We undertook this study to analyze whether BHT alters distal airway/alveolar epithelial cells (AECs) and extracellular matrix (ECM) signaling involved in the ...
Pulmonary Mastocytosis and Enhanced Lung Inflammation in Mice ...
Apr 17, 2008 · To assess effects of Foxf1 during lung injury, we used CCl 4 and butylated hydroxytoluene (BHT) injury models. Foxf1+/− mice developed severe airway obstruction and bronchial edema, associated with increased numbers of pulmonary mast cells and increased mast cell degranulation after injury.