Repairing damaged lungs using regenerative therapy - PMC
Moderate-to-extensive lung injury characterizes several lung diseases, and not only therapies that reduce such lung injury are needed but also those that regenerate lung tissue and repair existing lung injury.
Lung repair and regeneration: Advanced models and insights into …
Mar 15, 2024 · In response to frequent exposure to damaging agents, injury, and disease, the respiratory system has developed many strategies to repair and regenerate its structure and lost cells. The importance of these regenerative abilities has been underscored by the COVID-19 pandemic, which resulted in acute lung injury in millions of individuals worldwide.
Conceptual Approaches to Lung Injury and Repair - PMC
Aug 27, 2014 · Lung injury and repair is a broad topic that includes many cell types and is relevant to the pathogenesis of most lung diseases. Here, we focus on injury and repair of the alveolus, the principal function of which is to achieve gas exchange.
An injury-induced mesenchymal-epithelial cell niche coordinates …
How the distal lung decides between euplastic regeneration and dysplastic repair remains poorly characterized. Because of the high level of cellular diversity in the distal lung, it is unclear which cells contribute to the establishment of the injury-induced niche and whether these cells can be targeted to restore alveolar structure and function.
Repair after acute lung injury: molecular mechanisms and …
Mar 20, 2012 · There is increasing evidence of the lung's capacity to repair itself. This process involves an interplay between various cellular and molecular mechanisms, including resolution of edema and inflammation, cell proliferation and tissue remodeling.
The Cellular and Physiological Basis for Lung Repair and …
Apr 2, 2020 · In this review and as members of the NIH/NHLBI-supported Progenitor Cell Translational Consortium, we discuss key aspects of lung repair and regeneration. We focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new methods to study lung repair and regeneration.
Epithelial repair mechanisms in the lung | American Journal of ...
injury to the lung epithelium can be caused by bacterial or viral infections, inflammation, allergic reactions (asthma), exposure to xenobiotics (e.g., cigarette smoke), physical trauma (mechanical ventilation), cancer, or pathology of unknown origin (idiopathic fibrosis).
Acute Lung Injury, Repair, and Remodeling: Pulmonary …
Lung repair and remodeling following ALI are crucial steps and could be a risk factor for determining morbidity and mortality. During normal repair and remodeling phases, alveolar fluid is reabsorbed and debris from dead cells and pathogens is …
The three R’s of lung health and disease: repair, remodeling, and ...
Jun 1, 2011 · In this Review, we will discuss the connection between pathways required for lung development and how the lung responds to injury and disease, with a particular emphasis on recent studies describing the role for the epithelium in repair and regeneration.
How the lung repairs its wounds - ScienceDaily
Jul 14, 2015 · Our lungs are permanently exposed to harmful environmental factors that can damage or even destroy their cells. In a specific regenerative process these injured cells must be replaced as soon as...