Sequence homology - Wikipedia
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.
Expasy - SIM Alignment Tool
SIM is a program which finds a user-defined number of best non-intersecting alignments between two protein sequences or within a sequence [more]. Once the alignment is computed, you can view it using LALNVIEW, a graphical viewer program for …
What is sequence alignment and what methods are used for it?
Nov 23, 2023 · Sequence alignment is a fundamental technique in bioinformatics that involves arranging the residues of two or more biological sequences—typically DNA, RNA, or protein sequences—in a way that highlights their similarities and differences.
Basics of sequence similarity and homology searches
Sep 28, 2023 · Sequence similarity and homology searches are fundamental in exploring sequence databases using alignment to a query sequence. It’s pivotal for detecting sequences that are homologous, meaning they share common ancestry and likely analogous functions.
Homology - Site Guide - NCBI - National Center for …
A collection of sequence alignments and profiles representing protein domains conserved in molecular evolution. It also includes alignments of the domains to known 3-dimensional protein structures in the MMDB database.
Homology • homologous sequences can be divided into two groups – orthologous sequences: sequences that differ because they are found in different species (e.g. human α-globin and mouse α-globin) – paralogous sequences: sequences that differ because of a gene duplication event (e.g. human α-globin and
Protein remote homology detection and structural alignment
Sep 7, 2023 · Exploiting sequence–structure–function relationships in biotechnology requires improved methods for aligning proteins that have low sequence similarity to previously annotated proteins. We...
Muscle5: High-accuracy alignment ensembles enable unbiased
Nov 15, 2022 · Multiple sequence alignments are widely used to infer evolutionary relationships, enabling inferences of structure, function, and phylogeny. Standard practice is to construct one alignment by...
Homology assessment and molecular sequence alignment
Feb 1, 2006 · Sequence alignment is the process by which we assign putative homology to molecular data. The NW algorithm simply maximizes similarity within a specific cost regime, but this is the recognition criterion of homology.
HAlign 4: a new strategy for rapidly aligning millions of sequences
Nov 28, 2024 · HAlign is a high-performance multiple sequence alignment software based on the star alignment strategy, which is the preferred choice for rapidly aligning large numbers of sequences. HAlign3, implemented in Java, is the latest version capable of aligning an ultra-large number of similar DNA/RNA sequences.
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